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KMID : 1059520110550060994
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Journal of the Korean Chemical Society
2011 Volume.55 No. 6 p.994 ~ p.999
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Studies on Some Bioactive 1,1-Bis(2-benzylidene-5-aryliden-1,3-thiadiazolidin-4-one)cyclopropane
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Hemant Panwar
Nidhi Chaudhary
Sachi Singh
Amit Chawla
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Abstract
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Some novel heterocyclic derivatives of 1,1-bis(2-phenyl-5-arylidine-1,3-thiadiazolidin-4-one)cyclopropane 4(a-i) have been synthesized from cyclopropane dicarboxylic acid and substituted thiadiazole moieties. All the synthesized compounds have been characterized by elemental and spectral (I.R., 1H-NMR, Mass) analysis. Furthermore, above said compounds were screened for their antifungal and antibacterial activities. Compound 4c was found the most potent one which further evaluated for lesser toxicity test.
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KEYWORD
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Bis-phenylarylidinylthiadiazolidinone cyclopropane, Antifungal, Antibacterial, Acute toxicity
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